ECB-ART-34941
Dev Biol
1983 Nov 01;1001:197-206. doi: 10.1016/0012-1606(83)90211-7.
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Most early-variant histone mRNA is contained in the pronucleus of sea urchin eggs.
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Previous studies demonstrated that the pronucleus of the unfertilized sea urchin egg contains a high concentration of transcripts complementary to the early histone repeat unit (D. L. Venezky, L. M. Angerer, and R. C. Angerer (1981). Cell 24, 385-391.) In this paper, in situ hybridization techniques of improved sensitivity are used to show that these nuclear RNAs include authentic histone mRNA but not spacer-complementary sequences. It is estimated that most early-variant histone mRNA contained in the egg is, in fact, restricted to the pronucleus. These mRNAs are released to the cytoplasm at the time of nuclear breakdown of first cleavage and rapidly distribute throughout the cytoplasm.
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Genes referenced: LOC100887844 LOC115919910