ECB-ART-35882
Comp Biochem Physiol C Comp Pharmacol Toxicol
1993 Sep 01;1061:269-73. doi: 10.1016/0742-8413(93)90282-p.
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Possibility of membrane reception of neurotransmitter in sea urchin early embryos.
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1. Methiodide derivatives of serotonin blockers--inmecarb and KYur-14 which poorly penetrate the cells specifically affect the pattern of cleavage division in half-embryos of Paracentrotus lividus and Scaphechinus mirabilis. 2. Specific [3H]8-OH-DPAT binding under conditions strictly limiting penetration of the ligand into the cells of Strongylocentrotus intermedius was also shown (Kd approximately 3 x 10(-10) M for a site with the greatest affinity). 3. On the basis of the data obtained it is concluded that neurotransmitter-specific membrane receptors may be present in sea urchin embryos during cleavage divisions. The "protosynapse" hypothesis is proposed which suggests the existence of a specific structure responsible for early blastomere interaction involving transmitters.
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Genes referenced: LOC100887844 LOC100888622