ECB-ART-36203
FEBS Lett
1993 Mar 08;3183:259-63. doi: 10.1016/0014-5793(93)80524-x.
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Cyclic ADP-ribose-induced Ca2+ release from rat brain microsomes.
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Cyclic ADP-ribose (cADPR), an endogenous NAD+ metabolite in many mammalian and invertebrate tissues, is a potent mediator of calcium mobilization in sea urchin eggs. Our results show that cADPR also stimulates calcium release from rat brain microsomes, marked release occurring over the concentration range 10-250 nM. This is not inhibited by concentrations of heparin which completely abolish inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release. Ryanodine (100 microM) inhibits the cADPR response. Our results are consistent with cADPR being an endogenous messenger mediating Ca2+ release from ryanodine-sensitive pools in brain.
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Genes referenced: LOC100887844 LOC115919080