ECB-ART-40073
Bull Exp Biol Med
2006 May 01;1415:584-7. doi: 10.1007/s10517-006-0227-8.
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Neurotrophic effects of polyhydroxylated steroids and steroid glycosides in cultured neuroblastoma cells.
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The effects of steroid compounds from Pacific Ocean starfishes were studied using cultured neuroblastoma C-1300 cells. Vital observations and examination of silver-impregnated preparations showed that the test substances in a concentration of 2-10 microM stimulate differentiation and improves survival of neuroblastoma cells under adverse conditions (similarly to neurotrophins). These substances in high concentrations (20-40 microM) had no effect or exhibited cytotoxic activity. The screening test allowed us to select several compounds for further studies of neurotrophic and neuroprotective properties.
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