ECB-ART-32406
Cell Differ Dev
1988 Nov 01;25 Suppl:15-8. doi: 10.1016/0922-3371(88)90094-9.
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G-proteins and egg activation.
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G-proteins are present in eggs, and experiments in which GTP-gamma-S, GDP-beta-S, cholera toxin and pertussis toxin have been injected into eggs have indicated the involvement of G-proteins in egg activation at fertilization and in oocyte maturation. Eggs into which serotonin or muscarinic acetylcholine receptors have been introduced by mRNA injection produce fertilization-like responses when exposed to serotonin or acetylcholine; since these neurotransmitter receptors act by way of G-proteins, this observation further supports the conclusion that a G-protein is involved in the fertilization process.
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Genes referenced: LOC100888622 LOC577998 LOC590297