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J Bioenerg Biomembr
1997 Jun 01;293:233-9. doi: 10.1023/a:1022406026196.
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Lineage-specific evolution of echinoderm mitochondrial ATP synthase subunit 8.
De Giorgi C
,
Martiradonna A
,
Pesole G
,
Saccone C
.
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Peculiar evolutionary properties of the subunit 8 of mitochondrial ATP synthase (ATPase8) are revealed by comparative analyses carried out between both closely and distantly related species of echinoderms. The analysis of nucleotide substitution in the three echinoids demonstrated a relaxation of amino acid functional constraints. The deduced protein sequences display a well conserved domain at the N-terminus, while the central part is very variable. At the C-terminus, the broad distribution of positively charged amino acids, which is typical of other organisms, is not conserved in the two different echinoderm classes of the sea urchins and of the sea stars. Instead, a motif of three amino acids, so far not described elsewhere, is conserved in sea urchins and is found to be very similar to the motif present in the sea stars. Our results indicate that the N-terminal region seems to follow the same evolutionary pattern in different organisms, while the maintenance of the C-terminal part in a phylum-specific manner may reflect the co-evolution of mitochondrial and nuclear genes.
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,
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Crozier,
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,
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Devereux,
A comprehensive set of sequence analysis programs for the VAX.
1984,
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Fearnley,
Two overlapping genes in bovine mitochondrial DNA encode membrane components of ATP synthase.
1986,
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Gouy,
ACNUC--a portable retrieval system for nucleic acid sequence databases: logical and physical designs and usage.
1989,
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Grasso,
The C-terminal positively charged region of subunit 8 of yeast mitochondrial ATP synthase is required for efficient assembly of this subunit into the membrane F0 sector.
1991,
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Hadikusumo,
The definition of mitochondrial H+ ATPase assembly defects in mit- mutants of Saccharomyces cerevisiae with a monoclonal antibody to the enzyme complex as an assembly probe.
1988,
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Kyte,
A simple method for displaying the hydropathic character of a protein.
1982,
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Law,
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1990,
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Nagley,
Eukaryote membrane genetics: the Fo sector of mitochondrial ATP synthase.
1989,
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Okimoto,
The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum.
1992,
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Papakonstantinou,
Relationship of subunit 8 of yeast ATP synthase and the inner mitochondrial membrane. Subunit 8 variants containing multiple lysine residues in the central hydrophobic domain retain function.
1995,
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Rost,
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1994,
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Rzhetsky,
Tests of applicability of several substitution models for DNA sequence data.
1995,
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Saccone,
Influence of base composition on quantitative estimates of gene evolution.
1990,
Pubmed
Senior,
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1988,
Pubmed
Velours,
Localisation of the hydrophilic C terminal part of the ATP synthase subunit 8 of Saccharomyces cerevisiae.
1986,
Pubmed
Walker,
ATP synthase from bovine mitochondria. The characterization and sequence analysis of two membrane-associated sub-units and of the corresponding cDNAs.
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