Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mol Cell Biol
2005 Nov 01;2521:9503-8. doi: 10.1128/MCB.25.21.9503-9508.2005.
Show Gene links
Show Anatomy links
Canonical Notch signaling is dispensable for early cell fate specifications in mammals.
Shi S, Stahl M, Lu L, Stanley P.
???displayArticle.abstract???
The canonical Notch signaling pathway mediated by Delta- and Jagged-like Notch ligands determines a variety of cell fates in metazoa. In Caenorhabditis elegans and sea urchins, canonical Notch signaling is essential for different cell fate specifications during early embryogenesis or the formation of endoderm, mesoderm, or ectoderm germ layers. Transcripts of Notch signaling pathway genes are present during mouse blastogenesis, suggesting that the canonical Notch signaling pathway may also function in early mammalian development. To test this directly, we used conditional deletion in oocytes carrying a ZP3Cre recombinase transgene to generate mouse embryos lacking both maternal and zygotic protein O-fucosyltransferase 1, a cell-autonomous and essential component of canonical Notch receptor signaling. Homozygous mutant embryos derived from eggs lacking Pofut1 gene transcripts developed indistinguishably from the wild type until approximately embryonic day 8.0, a postgastrulation stage after the formation of the three germ layers. Thus, in contrast to the case with C. elegans and sea urchins, canonical Notch signaling is not required in mammals for earliest cell fate specifications or for formation of the three germ layers. The use of canonical Notch signaling for early cell fate specifications by lower organisms may represent co-option of a regulatory pathway originally used later in development by all metazoa.
Angerer,
Patterning the sea urchin embryo: gene regulatory networks, signaling pathways, and cellular interactions.
2003, Pubmed,
Echinobase
Angerer,
Patterning the sea urchin embryo: gene regulatory networks, signaling pathways, and cellular interactions.
2003,
Pubmed
,
Echinobase Artavanis-Tsakonas,
Notch signaling: cell fate control and signal integration in development.
1999,
Pubmed Bally-Cuif,
Coregulation of anterior and posterior mesendodermal development by a hairy-related transcriptional repressor.
2000,
Pubmed Baron,
Multiple levels of Notch signal regulation (review).
2002,
Pubmed Bellotto,
Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome.
2002,
Pubmed Campos-Ortega,
Genetic mechanisms of early neurogenesis in Drosophila melanogaster.
1995,
Pubmed Chen,
Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1.
2001,
Pubmed Cormier,
Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.
2004,
Pubmed de Vries,
Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes.
2000,
Pubmed Donoviel,
Mice lacking both presenilin genes exhibit early embryonic patterning defects.
1999,
Pubmed Dosch,
Maternal control of vertebrate development before the midblastula transition: mutants from the zebrafish I.
2004,
Pubmed Good,
The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos.
2004,
Pubmed Hahn,
Lunatic fringe null female mice are infertile due to defects in meiotic maturation.
2005,
Pubmed Haines,
Glycosylation regulates Notch signalling.
2003,
Pubmed Hamatani,
Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation.
2004,
Pubmed Hamatani,
Dynamics of global gene expression changes during mouse preimplantation development.
2004,
Pubmed Herreman,
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
1999,
Pubmed Ioffe,
WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras.
1995,
Pubmed Johnson,
Notch pathway genes are expressed in mammalian ovarian follicles.
2001,
Pubmed Kemler,
Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast.
2004,
Pubmed Kikuchi,
Notch signaling can regulate endoderm formation in zebrafish.
2004,
Pubmed Koo,
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
2005,
Pubmed Lan,
Differential oocyte-specific expression of Cre recombinase activity in GDF-9-iCre, Zp3cre, and Msx2Cre transgenic mice.
2004,
Pubmed Lei,
An O-fucose site in the ligand binding domain inhibits Notch activation.
2003,
Pubmed Levine,
Gene regulatory networks for development.
2005,
Pubmed
,
Echinobase Luo,
O-fucosylation of notch occurs in the endoplasmic reticulum.
2005,
Pubmed Moskowitz,
lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans.
1996,
Pubmed Mumm,
Notch signaling: from the outside in.
2000,
Pubmed Oka,
Disruption of the mouse RBP-J kappa gene results in early embryonic death.
1995,
Pubmed Okajima,
Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding.
2005,
Pubmed Okajima,
Regulation of notch signaling by o-linked fucose.
2002,
Pubmed Okajima,
Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe.
2003,
Pubmed Panin,
Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe.
2002,
Pubmed Pelegri,
Identification of recessive maternal-effect mutations in the zebrafish using a gynogenesis-based method.
2004,
Pubmed Peterson,
A Fringe-modified Notch signal affects specification of mesoderm and endoderm in the sea urchin embryo.
2005,
Pubmed
,
Echinobase Pires-daSilva,
The evolution of signalling pathways in animal development.
2003,
Pubmed Priess,
The glp-1 locus and cellular interactions in early C. elegans embryos.
1987,
Pubmed Raff,
Modularity and dissociation in the evolution of gene expression territories in development.
2000,
Pubmed
,
Echinobase Riddle,
Specification of Cell Fates in the Early Embryo
1997,
Pubmed Sasamura,
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions.
2003,
Pubmed Shafi,
The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.
2000,
Pubmed Sherwood,
Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation.
1997,
Pubmed
,
Echinobase Sherwood,
LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.
1999,
Pubmed
,
Echinobase Sherwood,
LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo.
2001,
Pubmed
,
Echinobase Shi,
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways.
2003,
Pubmed Shi,
Inactivation of the Mgat1 gene in oocytes impairs oogenesis, but embryos lacking complex and hybrid N-glycans develop and implant.
2004,
Pubmed Steele,
Developmental signaling in Hydra: what does it take to build a "simple" animal?
2002,
Pubmed Stollewerk,
Involvement of Notch and Delta genes in spider segmentation.
2003,
Pubmed Strobl,
Both Epstein-Barr viral nuclear antigen 2 (EBNA2) and activated Notch1 transactivate genes by interacting with the cellular protein RBP-J kappa.
1997,
Pubmed Su,
A gene atlas of the mouse and human protein-encoding transcriptomes.
2004,
Pubmed Sweet,
LvDelta is a mesoderm-inducing signal in the sea urchin embryo and can endow blastomeres with organizer-like properties.
2002,
Pubmed
,
Echinobase Wagner,
Maternal control of development at the midblastula transition and beyond: mutants from the zebrafish II.
2004,
Pubmed Wang,
A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo.
2004,
Pubmed Weinmaster,
Modulation of notch signaling during somitogenesis.
2003,
Pubmed White,
Defective somite patterning in mouse embryos with reduced levels of Tbx6.
2003,
Pubmed Wodarz,
Asymmetric cell division during neurogenesis in Drosophila and vertebrates.
2003,
Pubmed
