ECB-ART-40102
Biochem Biophys Res Commun
2007 Mar 16;3543:668-75. doi: 10.1016/j.bbrc.2007.01.035.
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Sp-tetraKCNG: A novel cyclic nucleotide gated K(+) channel.
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The sequence of a novel cGMP-regulated, tetrameric, K(+) selective channel (Sp-tetraKCNG) was discovered in the sea urchin Strongylocentrotus purpuratus. The Sp-tetraKCNG is a single polypeptide made of four KCNG domains similar to voltage-dependent Na(+) and Ca(2+) channels. Each KCNG domain has six transmembrane segments (S1-S6), the ion pore having the K(+) selectivity signature GYGD and a cyclic nucleotide-binding domain (CNBD). This novel channel is evolutionary located between K(+)-selective and voltage-dependent EAG channels and voltage-independent cationic CNG channels. Bilayer reconstitutions demonstrate such a cGMP-regulated K(+) selective channel in sea urchin spermatozoa.
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Genes referenced: LOC100887844 LOC115917877 tetrakcng