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ECB-ART-41127
Biosci Biotechnol Biochem 2009 May 01;735:1203-5. doi: 10.1271/bbb.80793.
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Effects of Ca2+ on refolding of the recombinant hemolytic lectin CEL-III.

Hisamatsu K , Unno H , Goda S , Hatakeyama T .


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CEL-III is a hemolytic lectin isolated from Cucumaria echinata. Although recombinant CEL-III (rCEL-III) expressed in Escherichia coli showed very weak hemolytic activity compared with native protein, it was considerably enhanced by refolding in the presence of Ca(2+). This suggests that Ca(2+) supported correct folding of the carbohydrate-binding domains of rCEL-III, leading to effective binding to the cell surface and subsequent self-oligomerization.

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Genes referenced: LOC115919910