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???displayArticle.abstract??? Foxa is a forkhead transcription factor that is expressed in the endoderm lineage across metazoans. Orthologs of foxa are expressed in cells that intercalate, polarize, and form tight junctions in the digestive tracts of the mouse, the sea urchin, and the nematode and in the chordate notochord. The loss of foxa expression eliminates these morphogenetic processes. The remarkable similarity in foxa phenotypes in these diverse organisms raises the following questions: why is the developmental role of Foxa so highly conserved? Is foxa transcriptional regulation as conserved as its developmental role? Comparison of the regulation of foxa orthologs in sea urchin and in Caenorhabditis elegans shows that foxa transcriptional regulation has diverged significantly between these two organisms, particularly in the cells that contribute to the C. elegans pharynx formation. We suggest that the similarity of foxa phenotype is due to its role in an ancestral gene regulatory network that controlled intercalation followed by mesenchymal-to-epithelial transition. foxa transcriptional regulation had evolved to support the developmental program in each species so foxa would play its role controlling morphogenesis at the necessary embryonic address.
Abdelkhalek,
The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.
2004, Pubmed
Abdelkhalek,
The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.
2004,
Pubmed Ang,
HNF-3 beta is essential for node and notochord formation in mouse development.
1994,
Pubmed Anokye-Danso,
Transcription factors GATA/ELT-2 and forkhead/HNF-3/PHA-4 regulate the tropomyosin gene expression in the pharynx and intestine of Caenorhabditis elegans.
2008,
Pubmed Azzaria,
A fork head/HNF-3 homolog expressed in the pharynx and intestine of the Caenorhabditis elegans embryo.
1996,
Pubmed Ben-Tabou de-Leon,
Gene regulation: gene control network in development.
2007,
Pubmed
,
Echinobase Ben-Tabou de-Leon,
Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology.
2009,
Pubmed
,
Echinobase Bossard,
GATA transcription factors as potentiators of gut endoderm differentiation.
1998,
Pubmed Boyle,
Developmental expression of foxA and gata genes during gut formation in the polychaete annelid, Capitella sp. I.
2008,
Pubmed Broitman-Maduro,
The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C. elegans mesoderm development.
2009,
Pubmed Burtscher,
Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo.
2009,
Pubmed Capo-Chichi,
Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells.
2005,
Pubmed Chen,
Function of the PHA-4/FOXA transcription factor during C. elegans post-embryonic development.
2008,
Pubmed Davidson,
An integrated view of precambrian eumetazoan evolution.
2009,
Pubmed de-Leon,
Information processing at the foxa node of the sea urchin endomesoderm specification network.
2010,
Pubmed
,
Echinobase Erwin,
The evolution of hierarchical gene regulatory networks.
2009,
Pubmed Fraser,
An ancient gene network is co-opted for teeth on old and new jaws.
2009,
Pubmed Friedman,
The Foxa family of transcription factors in development and metabolism.
2006,
Pubmed Fritzenwanker,
Analysis of forkhead and snail expression reveals epithelial-mesenchymal transitions during embryonic and larval development of Nematostella vectensis.
2004,
Pubmed Gao,
Transfer of a large gene regulatory apparatus to a new developmental address in echinoid evolution.
2008,
Pubmed
,
Echinobase Gao,
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
2008,
Pubmed Gaudet,
Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4.
2002,
Pubmed Hardin,
Local shifts in position and polarized motility drive cell rearrangement during sea urchin gastrulation.
1989,
Pubmed
,
Echinobase Harvey,
NK-2 homeobox genes and heart development.
1996,
Pubmed Hinman,
Developmental gene regulatory network architecture across 500 million years of echinoderm evolution.
2003,
Pubmed
,
Echinobase Hinman,
Evolutionary plasticity of developmental gene regulatory network architecture.
2007,
Pubmed
,
Echinobase Holland,
AmphiNk2-tin, an amphioxus homeobox gene expressed in myocardial progenitors: insights into evolution of the vertebrate heart.
2003,
Pubmed Horner,
pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans.
1998,
Pubmed Hotta,
Brachyury-downstream gene sets in a chordate, Ciona intestinalis: integrating notochord specification, morphogenesis and chordate evolution.
2008,
Pubmed Imai,
(beta)-catenin mediates the specification of endoderm cells in ascidian embryos.
2000,
Pubmed Istrail,
Logic functions of the genomic cis-regulatory code.
2005,
Pubmed
,
Echinobase Istrail,
The regulatory genome and the computer.
2007,
Pubmed Jeong,
Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node.
2003,
Pubmed Kiefer,
PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut.
2007,
Pubmed Kim,
Cell fate polarization in ascidian mesenchyme/muscle precursors by directed FGF signaling and role for an additional ectodermal FGF antagonizing signal in notochord/nerve cord precursors.
2007,
Pubmed Kimura-Yoshida,
Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.
2007,
Pubmed Koinuma,
Planaria FoxA (HNF3) homologue is specifically expressed in the pharynx-forming cells.
2000,
Pubmed Kozmik,
Pax genes in eye development and evolution.
2005,
Pubmed Kumano,
Overlapping expression of FoxA and Zic confers responsiveness to FGF signaling to specify notochord in ascidian embryos.
2006,
Pubmed Lemons,
Co-option of an anteroposterior head axis patterning system for proximodistal patterning of appendages in early bilaterian evolution.
2010,
Pubmed Lickert,
Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.
2002,
Pubmed Lin,
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.
2009,
Pubmed Logan,
Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo.
1999,
Pubmed
,
Echinobase Mango,
The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans.
1994,
Pubmed Mango,
The molecular basis of organ formation: insights from the C. elegans foregut.
2009,
Pubmed Marcellini,
Evolution of Brachyury proteins: identification of a novel regulatory domain conserved within Bilateria.
2003,
Pubmed McCauley,
A conserved gene regulatory network subcircuit drives different developmental fates in the vegetal pole of highly divergent echinoderm embryos.
2010,
Pubmed
,
Echinobase Munro,
Polarized basolateral cell motility underlies invagination and convergent extension of the ascidian notochord.
2002,
Pubmed Murakami,
GATA factors as key regulatory molecules in the development of Drosophila endoderm.
2005,
Pubmed Murray,
Automated analysis of embryonic gene expression with cellular resolution in C. elegans.
2008,
Pubmed Oliveri,
Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo.
2006,
Pubmed
,
Echinobase Owraghi,
Roles of the Wnt effector POP-1/TCF in the C. elegans endomesoderm specification gene network.
2010,
Pubmed Panowski,
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
2007,
Pubmed Passamaneck,
Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis.
2009,
Pubmed Peter,
The endoderm gene regulatory network in sea urchin embryos up to mid-blastula stage.
2010,
Pubmed
,
Echinobase Pichaud,
Pax genes and eye organogenesis.
2002,
Pubmed Range,
LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo.
2005,
Pubmed
,
Echinobase Ransick,
cis-regulatory processing of Notch signaling input to the sea urchin glial cells missing gene during mesoderm specification.
2006,
Pubmed
,
Echinobase Rojas,
Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer.
2010,
Pubmed Ruiz i Altaba,
Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3 beta.
1995,
Pubmed Sasaki,
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.
1993,
Pubmed Shimeld,
Characterisation of amphioxus HNF-3 genes: conserved expression in the notochord and floor plate.
1997,
Pubmed Smith,
Role of T-box gene tbx-2 for anterior foregut muscle development in C. elegans.
2007,
Pubmed Song,
Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer.
2010,
Pubmed Soudais,
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro.
1995,
Pubmed Stemple,
The notochord.
2004,
Pubmed Suri,
Inhibition of mesodermal fate by Xenopus HNF3beta/FoxA2.
2004,
Pubmed Tamplin,
Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
2008,
Pubmed Tang,
FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers.
2011,
Pubmed Technau,
Brachyury, the blastopore and the evolution of the mesoderm.
2001,
Pubmed Wan,
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.
2005,
Pubmed Weinstein,
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.
1994,
Pubmed Weitzel,
Differential stability of beta-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled.
2004,
Pubmed
,
Echinobase Wikramanayake,
Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages.
2004,
Pubmed
,
Echinobase Yamanaka,
Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms.
2007,
Pubmed Zorn,
Molecular basis of vertebrate endoderm development.
2007,
Pubmed
