ECB-ART-42550
Biochem Biophys Res Commun
2012 Aug 31;4253:583-7. doi: 10.1016/j.bbrc.2012.07.132.
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The quest for the sea urchin egg receptor for sperm.
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This review discusses identification, isolation and characterization of proteins mediating species-selective sperm-to-egg adhesion during sea urchin fertilization. Bindin is the only sea urchin sperm protein known to mediate species-selective sperm attachment to eggs. Two completely different egg surface proteins, 350-kDa and EBR1, have affinity for bindin and each one meets all the criteria to be a species-selective sperm receptor. Experiments suggest that sperm bindin recognizes both the sulfated O-linked oligosaccharides on the egg 350-kDa glycoprotein, and also the repeated protein sequence modules of EBR1.
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Genes referenced: bindin ebr1 LOC100887844