ECB-ART-48453
Biochem Biophys Res Commun
2018 Jun 22;5012:387-393. doi: 10.1016/j.bbrc.2018.04.212.
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Novel phosphorelay-dependent control of ZFP36L1 protein during the cell cycle.
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The ZFP36 family is a prototypical member of a highly conserved group of proteins with CCCH-type RNA-binding domains, whose functional role and regulatory mechanism in mitotic cells remain obscure. In this study, we provide the first evidence that ZFP36L1 phosphorylation is modulated in a cell cycle-dependent manner. The C-terminal region of ZFP36L1 is critical for its cell cycle-dependent phosphorylation of this protein. We also suggest that the phosphorelay-dependent regulation of ZFP36L1 influences mitotic spindle organization. Thus, our data demonstrate a new class of regulatory mechanism for CCCH-type zinc-finger proteins in cell cycle control.
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Genes referenced: LOC115919910 zfp36l1