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Zhongguo Fei Ai Za Zhi
2022 Sep 20;259:696-700. doi: 10.3779/j.issn.1009-3419.2022.102.29.
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[A Case of Advanced Lung Squamous Cell Carcinoma with CLIP1-ALK Fusion Gene].
Yuan Y
,
Wang Z
,
Nie X
,
Zhang P
,
Li L
.
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Anaplastic lymphoma kinase (ALK) fusion gene is an important tumor driver gene of non-small cell lung cancer, accounting for about 5% of patients with non-small cell lung cancer, of which 97% are patients with lung adenocarcinoma. Since the first discovery of echinoderm microtubule associated protein-like 4 (EML4)-ALK fusion in patients with lung adenocarcinoma in 2007, a variety of ALK fusion partners have been detected. CLIP1-ALK fusion gene was detected by next generation sequencing (NGS) in this patient with advanced lung squamous cell carcinoma, and Alectinib and Ensartinib were taken orally on May 5, 2021. Aletinib was effective for this patient but the patients died on September 30, 2021. This is a report of lung squamous cell carcinoma patients with CLIP1-ALK fusion gene treated with ALK inhibitors. .
图 2. 患者胸腔积液ALK荧光原位杂交结果Results of ALK fluorescence in situ hybridization in pleural effusion. ALK: anaplastic lymphoma kinase.
图 3. 胸部CT对比。A：患者基线影像学检查（2021年4月26日）：可见左主支气管截断，左肺致密实变影（肿瘤病灶与肺不张分界不清），纵隔多发淋巴结肿大；B：2021年7月14日疗效评价：左肺肿块与左上肺分界不清，范围较前缩小，左上肺较前复张；纵隔及右侧肺门多发肿大淋巴结较前缩小；C：患者2021年9月15日疗效评价：左肺肿块，较前范围明显增大，伴左侧全肺不张，纵隔6区淋巴结较前明显增大。Chest CT contrast. A: Baseline imaging examination of patient (April 26, 2021): truncation of the left main bronchus, dense consolidation of the left lung (unclear boundary between tumor and atelectasis) and multiple mediastinal lymph gland can be seen; B: Effect evaluation on July 14, 2021: the boundary between the left lung mass and the left upper lung is unclear, the scope is narrower than before, and the left upper lung is more dilated than before; the mediastinum and the right hilum of the lung were multiple and the lymph nodes were smaller than before; C: Effect of evaluation on September 15, 2021: the left lung mass is significantly larger than before, accompanied by left total atelectasis, and para-aortic lymph nodes was significantly larger than before. CT: computed tomography.
